The next evolution
in skin rejuvenation.
Dezawa MuseExosomes®
Derived from Dezawa MuseCells, these cell free exosomes carry growth factors and regenerative signals directly into the skin, amplifying results from microneedling and advanced facial treatments at Russak Dermatology Clinic.
No live cells. No downtime risk. Just targeted biological messaging that tells your skin how to repair, rebuild, and renew.
The Foundation
Understanding MuseCells
MuseCells (Multilineage differentiating Stress Enduring cells) are a naturally occurring population of pluripotent stem cells discovered by Professor Mari Dezawa at Tohoku University. Unlike embryonic or induced pluripotent stem cells, MuseCells already exist within your own body, residing quietly in bone marrow, skin, and connective tissue.
How MuseCells differ from other stem cells
Because they already exist in adult tissue, they are not embryonic cells. After injury, they home to damaged areas through SDF-1 signaling. In addition, they can become the cell type the tissue needs, whether that is skin, nerve, or cardiac cells.
What makes them remarkable is their ability to sense damage. When tissue is injured, MuseCells migrate through the bloodstream via SDF-1 signaling, home to the damaged area, and spontaneously differentiate into the specific cell type needed for repair, whether that is a skin cell, nerve cell, or cardiac cell.
With over 120 peer reviewed publications worldwide, MuseCells represent one of the most validated regenerative cell populations in modern science. Their nontumorigenic nature (they do not form teratomas) sets them apart from other pluripotent stem cell types.
In regenerative aesthetics, Dezawa MuseCells serve as the parent cell from which MuseExosomes are derived, ensuring every exosome carries the uniquely potent regenerative cargo that only pluripotent stem cells can produce.
Understanding Exosomes
Tiny messengers,
profound results
Exosomes are nanoscale vesicles, 30 to 150 nanometers in diameter, naturally released by cells. They carry a cargo of growth factors, signaling peptides, and regenerative instructions from their parent cell to surrounding tissue.
Why the source cell matters
When derived from Dezawa MuseCells, these exosomes carry uniquely potent regenerative signals. Applied topically during microneedling, they penetrate skin through microchannels in the skin and deliver instructions that tell fibroblasts to produce collagen, reduce inflammation, and restore cellular communication.
Because they are cell free, there is no risk of immune reaction or uncontrolled cell growth. They are the message without the messenger, pure biological signaling optimized for aesthetic results.
The Evolution
From MuseCells to MuseExosomes
MuseCells®
Pluripotent stem cells discovered by Professor Mari Dezawa. They home to damaged tissue through SDF-1 signaling and differentiate into the needed cell type, making them powerful for systemic regeneration via IV infusion.
Validated in 120+ global publications. Best suited for whole body regenerative protocols where live cell integration is the goal.
MuseExosomes®
Tiny biological messengers naturally released by MuseCells. They carry growth factors, signaling peptides, and regenerative instructions without containing any live cells. Applied topically during professional treatments.
Cell free, lyophilized for stability, and purpose built for aesthetic applications: microneedling, skin rejuvenation, and advanced facial protocols.
The critical difference: Generic exosomes derive from generic cells. Dezawa MuseExosomes originate exclusively from Dezawa MuseCells, which are characterized and lyophilized under clinical grade protocols, ensuring a consistent, potent regenerative signal in every application.
The Protocol
Microneedling with MuseExosomes
A three step protocol that transforms standard microneedling into a regenerative treatment, delivering targeted cellular signals where they matter most.
Prepare & Microneedle
The skin is cleansed and treated with professional microneedling, creating thousands of precise microchannels in the epidermis and upper dermis. These channels serve as direct pathways for exosome delivery.
Apply MuseExosomes
The lyophilized Dezawa MuseExosomes are reconstituted and applied topically over the treated area. The nanoscale vesicles penetrate the open microchannels, reaching the dermal layer where collagen synthesis originates.
Signal & Regenerate
Once absorbed, the exosomes deliver growth factors and peptide signals to fibroblasts and keratinocytes, stimulating collagen production, reducing inflammation, and normalizing cellular communication for visible skin renewal.
Applications
What MuseExosomes treat
Fine Lines & Wrinkles
Exosome signaling stimulates collagen and elastin production, softening fine lines from within rather than filling or freezing them.
Sun Damage & Pigmentation
Growth factors normalize melanocyte activity, helping to even out sun induced discoloration and restore a balanced, luminous complexion.
Enlarged Pores & Texture
Combined microneedling and exosome therapy tightens pore structure and refines skin texture at the cellular level.
Skin Barrier Repair
Exosomes reinforce the skin’s cellular architecture, strengthening barrier function, reducing sensitivity, and improving hydration retention.
Post Procedure Recovery
Anti-inflammatory signals from exosomes accelerate healing after microneedling, with redness typically resolving in 6 to 12 hours versus 48 hours with standard treatment.
Age Related Skin Thinning
By restoring cell-to-cell communication, exosomes support natural cell turnover and help reverse the thinning and fragility that comes with biological aging.
Comparison
Why add exosomes?
What to Expect
Results timeline
Immediate Post Treatment
Mild redness resolves rapidly. Skin feels hydrated and subtly tighter. No significant downtime required.
Early Visible Improvement
Enhanced radiance and complexion clarity as exosome signaling normalizes pigment production and stimulates early collagen remodeling.
Full Collagen Response
Visible softening of fine lines, improved skin firmness, refined pore appearance, and measurably improved skin elasticity.
Sustained Renewal
Continued improvement in skin quality, tone, and texture. Periodic maintenance sessions sustain and compound results over time.
Cell Free & Nontumorigenic
No live cells means no risk of uncontrolled growth or immune rejection. Safe for all skin types.
Lyophilized for Stability
Freeze dried formulation maintains structural integrity and biological potency. Reconstituted fresh at time of treatment.
Professional Use Only
Administered by trained practitioners during in-office procedures. Protocol is tailored to each patient’s skin assessment and goals.
Pairs with Hyaluronic Acid
The Dezawa MuseExosomes & Hyaluronic Acid System combines exosome signaling with deep hydration for enhanced treatment outcomes.
Common Questions
Frequently asked questions
Dezawa MuseExosomes are nanoscale vesicles (30 to 150 nanometers) naturally released by Dezawa MuseCells, a type of pluripotent stem cell discovered by Professor Mari Dezawa. These exosomes carry growth factors, signaling peptides, and regenerative instructions from the parent cell. Unlike live cell therapies, exosomes are cell free, meaning they deliver biological signals without transplanting any cells into the body.
The difference is the source cell. Generic exosome products derive from generic cell lines, which produce a broad, nonspecific set of signals. Dezawa MuseExosomes originate exclusively from Dezawa MuseCells, pluripotent stem cells that are clinically characterized and validated in over 120 peer reviewed publications. This means they carry a uniquely potent and consistent regenerative cargo, purpose built for tissue repair and skin rejuvenation.
The treatment combines microneedling with topical application of MuseExosomes. Most patients describe a mild tingling sensation during the microneedling portion. A topical numbing cream is applied beforehand for comfort. Recovery is significantly faster than standard microneedling. Most patients experience mild redness that resolves within 6 to 12 hours, compared to 24 to 48 hours with traditional microneedling. You can typically return to normal activities the same day.
Most patients see visible improvement after a single session, with optimal results typically achieved through a series of 3 to 4 treatments spaced 4 to 6 weeks apart. Your dermatologist will create a personalized protocol based on your skin assessment, goals, and the specific concerns being addressed. Periodic maintenance sessions every 3 to 6 months help sustain and compound results over time.
Yes. Because MuseExosomes are cell free, there is no risk of immune rejection or allergic reaction. The exosomes contain no live cells and are nontumorigenic, making them suitable for all skin types, including sensitive skin. The anti-inflammatory properties of the exosomes actually help calm the skin during treatment, which is why recovery time is so much shorter than with standard microneedling alone.
Many patients notice improved skin hydration and radiance within the first 24 hours. Visible improvements in tone, texture, and fine lines typically appear within 14 days as exosome signaling stimulates early collagen remodeling. The full collagen response develops over 6 to 8 weeks, with continued improvement in firmness, elasticity, and pore refinement. Results compound with subsequent treatments.
Yes. MuseExosomes pair well with a variety of professional treatments. They are most commonly used with microneedling, but can also complement laser resurfacing, PRP therapy, and advanced facial protocols. The Dezawa MuseExosomes & Hyaluronic Acid System is specifically designed to combine exosome signaling with deep hydration for enhanced outcomes. Your dermatologist will recommend the best combination based on your individual treatment plan.
Schedule Your Treatment
Experience regenerative
skin rejuvenation
Our team will evaluate your skin, discuss your goals, and determine whether MuseExosome-enhanced microneedling is the right protocol for you.
Dezawa MuseExosomes are for professional topical use only. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Results may vary. Consult your dermatologist to determine if this treatment is appropriate for you.
